Research Studies
Learn more about ketamine research by browsing our collection of scholarly studies.
A proof-of-concept investigation into ketamine as a pharmacological treatment for alcohol dependence
Safety, Tolerability, and Real-World Effectiveness of Intravenous Ketamine in Older Adults With Treatment-Resistant Depression
Safety and tolerability of IV ketamine in adults with major depressive or bipolar disorder
Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures
Drug‑drug interactions between psychiatric medications and MDMA or psilocybin
Ketamine for the treatment of addiction: Evidence and potential mechanisms
Journey through the K-hole: Phenomenological aspects of ketamine use
Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder
The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation
Ketamine as a mental health treatment: Are acute psychoactive effects associated with outcomes?
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
Antidepressant Effects of Ketamine in Depressed Patients
Mechanisms of Ketamine Action as an Antidepressant
Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression
Maintenance Ketamine Treatment Produces Long-term Recovery from Depression
Glutamate NMDA receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
Signaling Pathways Underlying the Rapid Antidepressant Actions of Ketamine
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression
Does Childhood Trauma Impact Outcomes in Adults Receiving Ketamine for Depression?
Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors
Ketamine Safety and Tolerability in Clinical Trials for Treatment Resistant Depression
Ketamine as a promising prototype for a new generation of rapid-acting antidepressants
Effects of Ketamine on Explicit and Implicit Suicidal Cognition
Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up
Efficacy of Intravenous Ketamine for Treatment of Chronic Post-traumatic Stress Disorder
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
Acute and longer-term outcomes using ketamine as a clinical treatment at the Yale Psychiatric Hospital
Long-term outcome in outpatients with depression treated with acute and maintenance intravenous ketamine
Rapid Antidepressant Response with Ketamine: Is it the Solution to Resistant Depression?
Paradigms of Ketamine Treatment
Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses
Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature
Bridging the gap: an interdisciplinary perspective on ketamine in psychiatric disorders
A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders
Ketamine increases the amplitude of the 40-Hz auditory steady-state response in humans
Psychedelic Harm Reduction and Integration: A Transtheoretical Model for Clinical Practice
Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression
Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
The Effect of Ketamine Infusion Treatment Schedule on Depression Severity
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Ketamine infusion therapy first started at the Yale School of Medicine and has a rich and impressive history proving its safety and effectiveness.
Ketamine infusion therapy first started at the Yale School of Medicine and has a rich and impressive history proving its safety and effectiveness. Watch this short video to learn more.